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We also do not explicitly consider the multiple domain organization of proteins in our models.
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The putative proteins encoded by these chitinase and chitinase-like genes were predicted to have a multiple-domain organization that includes 1, 2 or 4 catalytic domains; 0, 1, 4 or 5 chitin-binding domains; 0 or 1 leader signal peptide or transmembrane-spanning domain and linker regions.
We find that in length-deviant domain superfamilies, additional lengths are associated with multiple roles such as substrate specificity, regulation, stability, generating interaction interfaces to form higher order complexes involving multiple domains in multimeric organizations etc.
Network analysis tools such as graph-theoretic analysis [ 6] and hierarchal clustering algorithms [ 12] were also adapted to compare domain organizations across multiple organisms.
We conducted multiple phylogenetic analyses on this large dataset and thoroughly analyzed the protein domain organization of the Snail related proteins.
The general domain organization of carbohydrate sorting receptors contains an exoplasmic domain with one or multiple carbohydrate recognition domains, a single transmembrane domain, and a cytoplasmic domain with sorting signals [41].
(A) Domain organization of the Bbp molecule.
a. Domain organization of the rice EULs.
(A) Domain organization of the ATRX and DAXX.
(A) Schematic diagram of domain organization of SCARB2.
(A) Domain organization of hDDX41, composing of DEAD domain and Helicase domain from N to C terminus.
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