In addition, this metabolic signature is the common denominator of multiple and diverse pathways; which means that if it is therapeutically targeted it might offer selectivity for malignant cells of diverse cellular and molecular origins.
The WNT signaling pathway is involved in ovarian cancer development via multiple, diverse mechanisms, including gene mutations and changes in pathway components such as extracellular inhibitors and intranuclear transcription cofactors.
Virtually all mammalian cell types express multiple members of the Src protein-tyrosine kinase family, which regulate diverse pathways involved in cell growth, survival, differentiation, adhesion, and migration [1].
Although there is no single function for WD-repeat proteins, they share a common role in scaffolding protein complexes, often with multiple and competing partners, thereby serving as hubs for spatiotemporal orchestration of signaling events across diverse pathways.
Since FOXO transcription factors are involved in multiple cellular processes, including DNA repair, cell cycle, apoptosis, metabolism and ageing, SIRT2 is also connected with these diverse pathways (Calnan & Brunet, 2008).
However, the pathway to regulatory approval, policy recommendation, and program introduction in low- and middle-income countries is complex, requiring engagement with multiple, diverse stakeholders.
Two sets of chemical compounds inhibiting diverse pathways were examined.
features extracted from the data stream of multiple, diverse sensors.
They provide multiple, diverse opportunities to come to life, together.
EBP1 appears to fulfill multiple diverse biological functions.
