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Two bioreducible poly amidoamine)s (PAAs) containing multiple disulfide linkages in the polymer backbone (SS-PAAs) were synthesized and used to form three types of nanocomplexes by self-assembly with human insulin, used as a negatively charged model protein at neutral pH.
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Another feature of these polymers is their multiple intra-chain disulfide linkages.
Next, the obtained HS PEG RGD was conjugated with HSA RV nanoparticles via disulfide linkages.
Open image in new window Figure 5 Location of intramolecular disulfide linkages in HEF.
The disulfide linkages are chemically labile in nature and have the ability to dissociate in response to various disulfide-reducing agents, especially, glutathione [10 12].
Disulfide linkages between the core and the arms conferred biodegradability on the stars.
The left part shows the head domain which contains six disulfide linkages and also two free cysteines.
We report here the influence of glutathione concentration on the cleavage efficiency of the stimuli-responsive disulfide linkages.
In this paper, we demonstrate the efficient degradation of epoxy resins with disulfide linkages synthesized from bis(4-glycidyloxyphenyl)disulfide 4-glycidyloxyphenyl disulfide
Another structural similar polymer PTX conjugate without disulfide bonds (P L-PTX)) was also P L-PTXd to verify the function of disulfide linkages.
Nanobody possessing multiple disulfide bonds is more stable and it could be stored in RT.
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