Exact(1)
Fitting all three criteria, we highlighted breast cancer susceptibility SNPs and a borderline lung cancer relevant SNP located in cancer-specific enhancers overlapping multiple distinct transcription associated factor ChIP-seq binding sites.
Similar(59)
Multiple distinct transport mechanisms may be induced by the parasites.
Therefore, our results suggested that there may be multiple, distinct mechanisms controlling the transcription of single-repeat R3 MYB genes.
All three of these genes are very large in size spanning from 59 to over 100 kb and each encodes multiple isoforms with at least two distinct transcription start sites (for review see [50]).
Independent lines of evidence suggested that a large fraction of human genes possess multiple promoters driving gene expression from distinct transcription start sites.
The expression of hnf6 in the developing embryo is triphasic, and loss-of-function analysis shows that the Hnf6 protein is a transcription factor that has multiple distinct roles in sea urchin development.
A recent comprehensive analysis of DNA binding preferences conducted for a large group of transcription factors revealed that approximately half of these factors recognized multiple distinct sequence motifs, indicating that DNA binding preferences of transcription factors may be more flexible than previously realized [31].
To our knowledge, this is the first demonstration of a transdominant Tat mutant that targets multiple, distinct steps in the HIV-1 replication cycle: proviral gene transcription, Rev-dependent mRNA transport and reverse transcription.
We conclude that the targeting of distinct transcription factors, leading to trans-activation of transcription of multiple promoters, involves distinct domains of the E1A proteins that are also required for oncogenic activity.
Hollenhorst, P.C. et al. DNA specificity determinants associate with distinct transcription factor functions.
The E2A gene-product contains two separable and functionally distinct transcription activation domains.
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