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Cosmopolitan genera can exist as multiple distinct genetic and even reproductive entities [6], [7].
The exception in our study is the 'Deep Slope' habitat that does contain multiple distinct genetic groups (Figures 2, 4).
We used homozygous and heteroallelic mutant combinations to assay behavior in multiple distinct genetic backgrounds.
Our screening result suggests that this damage process may involve multiple distinct genetic pathways.
This is exemplified by the species of L. monocytogenes which consists of multiple distinct genetic lineages.
First, genotyping populations en masse (rather than as individuals) is confounded by genetic heterogeneity, i.e., multiple, distinct genetic solutions with a similar phenotype (Wilkening et al. 2013).
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Given their highly selfing mode of reproduction in nature [ 6, 13], this suggests that a given fruit can be colonized by multiple individuals of distinct genetic backgrounds.
If used as an adjunct to standard validation methods this approach can leverage multiple distinct data types to improve genetic risk factor discovery/validation, promote effective science communication, and guide future research directions.
Different DR models in C. elegans may thus have distinct genetic requirements, and multiple DR pathways that extend lifespan may co-exist.
Such genetic analysis should reveal whether the trait is controlled by a single locus or multiple loci and whether there are distinct genetic sources of resistance in different accessions.
Sporadic dystonia is an umbrella term, comprising multiple phenotypic subtypes that may well have distinct genetic architectures.
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