Sentence examples for multiple distinct cell from inspiring English sources

The progression of lung cancer involves dynamic changes in the genome and a complex network of interactions between cancer cells with multiple, distinct cell types that form tumors. Combination therapy using different pharmaceuticals has been proven highly effective due to the ability to affect multiple cellular pathways involved in the disease progression.

This may reflect both the broad range of biological functions performed in/by CVS and the fact that it contains multiple distinct cell types.

They are complex tissues composed of multiple distinct cell types that participate in heterotypic interactions with one another.

During embryogenesis in humans, early embryonic cells progressively confine their lineage commitment by changing their developmental potential, i.e., their ability to develop into multiple distinct cell types [ 13].

For specificity index analysis of multiple distinct cell types, microarray data were preprocessed using Bioconductor package affy (Gautier et al., 2004) and normalized using Robust Multichip Average (Irizarry et al., 2003).

The understanding of the natural history of HCC is hampered by the variability of the tumour, which is influenced by the co-occurrence of multiple co-morbidity factors in the same patient as well as by the presence of multiple distinct cell lines in the liver that may develop into liver cell cancer [ 4].

Brain-specific genes may be expressed in multiple distinct neuronal cell types and in a way resemble house-keeping genes in terms of shared cell types.

Recent data from live-imaging studies and long-term fate-mapping experiments have demonstrated regionally restricted contributions from multiple distinct stem cell niches in the PSU during homeostasis (Ghazizadeh and Taichman, 2001; Morris et al., 2004; Levy et al., 2005; Jaks et al., 2008; Brownell et al., 2011; Page et al., 2013).

It has long been recognised that primary prostate cancers are generally multifocal composed of multiple genetically distinct cell clones.

Historically attempts to explain how multiple phenotypically distinct cell types arise within the crypt have assumed the creation of lineage-restricted progenitors that can be distinguished by different transcription factor profiles [ 1,2].

This is particularly relevant when comparing gene expression profiles in complex tissue with multiple, phenotypically distinct cell types, within a given tumour or between normal and cancer tissue where phenotypically normal cells adjacent to a tumour may exhibit altered gene expression profiles owing to their proximity to the tumour [ 32, 105].