When multiple disorders are present, the ophthalmologist attempts to identify the disorder causing the greatest limitation of vision.
Similar changes were also observed in other mental disorders, including Alzheimer's disease, ApoE Ɛ4 allele carriers, traumatic brain injury, major depression, epilepsy and autism [ 12, 31– 36], suggesting that multiple disorders are linked to some analogous disruption of the DMN.
Identifying the associations between human protein complexes and multiple disorders is essential for understanding disease mechanism and is also important to assist drug developers for the development of new diagnostics and therapeutics.
Therefore involvement of several different health care providers in managing multiple disorders is inevitable and often results in competing treatments, sub-optimal coordination and communication between care providers, or unnecessary replication of diagnostic tests or treatments [ 3, 7, 8].
The most frequently offered explanation for the biased estimates from clinic-based samples suggests that individuals with multiple disorders are more likely to be referred for treatment than individuals with a single disorder (Galbaud Du Fort et al. 1993; Kushner et al. 2008).
Multiple anxiety disorders were the rule, rather than an exception.
Multiple mental disorders were assessed as meeting criteria for two or more (≥2) disorders.
aWhen multiple neurologic disorders were present, the most dominant or limiting condition was used for this classification.
When multiple neurologic disorders were present for a single patient, the most dominant or limiting condition was used for this classification.
Given high rates of comorbidity among mental disorders, better methods to rapidly screen across multiple mental disorders are needed.
