When we separated the genes specific to one disease versus the rest, we confirmed our hypothesis that genes associated with multiple disorders tend to be more multifunctional than specific genes.
The predicted protein complexes and their association with multiple disorders corresponding to the specific disease classes.
Annotation of the clusters with human disease associations revealed that multiple disorders map to the network, with a significant correlation of schizophrenia within the glutamate receptor clusters.
The klotho gene has been suggested in 1997 using klotho mutant mice (kl/kl mice) with multiple disorders similar to human premature-aging syndrome [ 13].
Going from one test for one disorder to one test for multiple disorders has the potential to reduce costs per condition tested and can lead to test expansion if these new technologies can be integrated safely and effectively into newborn screening programs.
Similar changes were also observed in other mental disorders, including Alzheimer's disease, ApoE Ɛ4 allele carriers, traumatic brain injury, major depression, epilepsy and autism [ 12, 31– 36], suggesting that multiple disorders are linked to some analogous disruption of the DMN.
The classification can thus cut across categories and be used to study underlying constructs that may apply to multiple disorders.
These are interesting regions, as they can indicate sights of de novo variation that might contribute to multiple disorders.
There are multiple disorders which majorly contribute to the occurrence of premature aging, such as metabolic dysregulation, neurodegenerative diseases, inflammation and also tumorigenesis (Giblin et al., 2014).
However, till now there is only limited information on health care utilization patterns related to multiple disorders in the Netherlands.
