The evidence that loss of GPA33 contributes to increased severity of multiple intestinal disorders associated with intestinal permeability advocates Gpa33 –/– mice as an advantageous model in which to test novel therapeutics designed to restore barrier function.
They were used for the treatment and prevention of skeletal disorders associated with multiple myeloma and bone metastases from breast, prostate, lung and kidney cancers and other solid tumours.
Patients with the latter syndrome display a multiple-anomaly disorder associated with mental retardation, white matter anomalies in the brain, growth hormone deficiency, congenital aural atresia, orofacial cleft, and palate abnormalities.
Numerous disorders associated with AdoHcy accumulation suggest that this metabolite is capable of triggering multiple pathological mechanisms, presumably via inhibition of different AdoMet-dependent methyltransferases.
Recently international studies have focused on the mental disorders associated with such abuse and reports suggest that there is a greater likelihood of depression [ 6], multiple somatic complaints [ 7] and post-traumatic stress disorder symptomatology [ 8].
Fanconi anemia (FA) is a recessive disorder associated with progressive pancytopenia, multiple developmental defects, and marked predisposition to malignancies.
Virus-associated hemophagocytic syndrome is a fulminant disorder associated with systemic viral infection and characterized pathologically by multiple-organ infiltration of hemophagocytic histiocytes into the lymphoreticular tissues.
Virus-associated hemophagocytic syndrome (VAHS) is a fulminant disorder associated with systemic viral infection and characterized pathologically by multiple-organ infiltration of hemophagocytic histiocytes into the lymphoreticular tissues.
IgG4-related disease (IgG4-RD) is a systemic disorder associated with lesions characterized by mass formation in multiple specific organs.
The endoplasmic reticulum (ER) and mitochondria are important cellular organelles in maintaining cell homeostasis, and dysfunction of each part is associated with multiple disorders, especially metabolic diseases.
