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In genome-wide association studies (GWAS), multiple diseases with shared controls is one of the case control study designs.
This might be justified because cancer is not one disease but a conglomeration of multiple diseases, with widespread heterogeneity even within a single tumor type.
The majority (>90%) of co-localising QTL conditioned resistance to multiple diseases, with a stand-out hotspot region on the long arm of SBI-06, containing 15 QTL for 6 traits from 4 studies [ 33- 36].
For example, Ostro et al. (2010) estimated that the use of air conditioning could significantly reduce the effects of temperature on hospitalizations for multiple diseases, with 0.76% absolute reduction in excess risk of cardiovascular disease for every 10% increase in air conditioner ownership.
Sometimes mutations in different genes can give rise to similar phenotypes, eg, there have been dozens of genes identified in patients suffering from muscular dystrophies. 1 However, mutations in a single gene can also give rise to multiple diseases with varying phenotypes.
33 On the other hand, our results suggest that the effects of multiple diseases with respect to disability are equal to or less than the combined effects of each individual disease on the individual, rather than there being any synergistic statistical interaction between them.
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Modeling overall coral disease prevalence, multiple diseases each with a possibly distinct etiology, seems inappropriate.
Recent reports suggest that US28 might play a causative role in multiple diseases associated with HCMV infection.
As it stands, health systems all over the world are built around institutions, not people, and are not equipped to manage the complexity of patients with multiple diseases, who often live with mental health issues and the personal burden and social isolation that comes from being ill.
When multiple diseases are associated with a single HPO term, scores are accumulated.
Among those with multiple diseases, primary health care visits increased with advancing age, while specialist care dropped off.
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