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BTK is a promising target for the treatment of multiple diseases such as B cell malignances, asthma, and rheumatoid arthritis.
In the recent years, the involvements of pDCs in multiple diseases, such as chronic viral infections, autoimmune diseases, and different types of cancers, have been extensively investigated (Tang et al. 2010; Vermi et al. 2011; Swiecki and Colonna 2015).
The changed features during the resting state may serve as a marker to reflect the progress of multiple diseases, such as Alzheimer's disease [12], Parkinson's disease [26], and Autism spectrum disorder [27].
It also functions in multiple diseases such as cancer, tissue fibrosis and diabetes.
Generally, these interventions are sold to the patients with the promise that they can cure multiple diseases, such as infertility.
Defects in the apoptotic pathway can lead to multiple diseases, such as neurodegenerative diseases, autoimmune diseases, AIDS and cancer [ 1].
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Inflammation and angiogenesis drive the development and progression of multiple devastating diseases such as atherosclerosis, cancer, rheumatoid arthritis, and inflammatory bowel disease.
The very oldest people often experience multiple chronic diseases, such as heart failure, respiratory failure and dementia.
IL1 and CCL8 are prominent inflammatory cytokines implicated in multiple inflammatory diseases such as atherosclerosis, rheumatoid arthritis (RA) and Alzheimer's diseases [ 15, 16].
Such approaches do not acknowledge or address the common experience of older populations with multiple chronic diseases such as CVD and OA.
Recently, hepatic ER stress has been proven to have a role in multiple liver diseases, such as insulin resistance, hepatic steatosis, alcohol-induced injury, and cholestatic liver.
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