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Abnormality of DC development observed in ATM-deficient mice might explain the defect and malfunction of immune system of ATM patients and their multiple disease status.
Moreover, the fact that breast cancer is not a single homogeneous disease but consists of multiple disease status, each arising from a distinct molecular mechanism and having a distinct clinical progression path [ 6] makes the disease difficult to early detect.
Moreover, the fact that breast cancer is not a single homogeneous disease but consists of multiple disease status, each arising from a distinct molecular mechanism and having a distinct clinical progression path [ 5, 6], makes the disease difficult to detect in early stages.
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Based on the result from MCMC method, we select SNP nodes associated with edges whose posterior probabilities larger than 0. Since we consider the association of multiple SNPs with disease status at each step of the Markov chain in our MCMC method, the potential disease SNPs related with epistatic interactions will be kept in the final subset of SNPs.
Sanchez, E. et al. Serum B-cell maturation antigen is elevated in multiple myeloma and correlates with disease status and survival.
a 57-year-old male with coronary artery disease, status post multiple prior percutaneous interventions, with symptoms of angina at rest.
This approach has the advantage of taking into account information from multiple sources in estimating true disease status but, in its traditional form, requires a minimum of three conditionally independent tests [10], [12].
Therefore, the aim of the present study was to evaluate the expression of MALAT1 in bone marrow mononuclear cells from patients with multiple myeloma and with different disease status and healthy individuals.
Because there were multiple confounding covariates related to disease status, we restricted testing of covariate relationships to physiologically plausible relationships (see Methods section) and used a greedy search algorithm based on log-likelihood ratio testing, as implemented by the stepwise covariate method.
Because 26% of the sample had unknown residual disease status, we used multiple imputations in the primary analysis.We identified 6,013 women with stage IIIC and IV high-grade serous, 307 with clear cell, and 140 with mucinous histology.
It is possible that multiple variants can jointly contribute to disease status.
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