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25 Patients had baseline disease characteristics that included multiple disease sites and visceral disease affecting the liver and lung.
However, quantitative analysis of all bone metastases is a time-consuming task because patients with advanced prostatic cancer usually have multiple disease sites.
These findings confirm clinical observations from multiple disease sites that sentinel lymph node biopsy is best performed in patients with small localized tumors and grossly uninvolved lymph nodes.
While some studies included only a single disease site, quite a number also involved multiple disease sites like ours and were not restricted to a particular CAM [ 13- 16].
This approach can enable more rapid trial closure or acceleration than trials focusing on a specific disease site, depending upon patient response rates, and could permit FDA consideration of a drug for approval in multiple disease sites [ 20].
The high risks for the presence of bilateral breast disease or multiple disease sites in one organ, especially among younger men, in the current investigation as well as in prior investigations are a likely indicator of a hereditary cancer syndrome [ 3, 9].
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The PROMIS item banks were derived using item response theory (IRT) and developed through a rigorous process of literature review, focus groups across multiple diseases and sites, cognitive assessments, and expert consultation.
Over 50% of the patients had poorly differentiated tumours and multiple intra-abdominal disease sites although only a third of patients had disease that exceeded 5 cm diameter.
This holds true for number of disease sites (single, 42%; multiple, 27%), performance status (0, 41%; ⩾1, 27%), disease symptoms (absent, 41%; present, 26%), previous loss of body weight (absent, 39%; present, 24%), previous radical surgery (yes, 38%; no, 23%).
Three patients (#6, 7, 8) had deep locations of disease sites and presented with multiple lesions at the same time.
Multiple biological barriers exist for drugs to successfully reach their intended disease sites.
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multiple disease mechanisms
multiple disease phenotypes
multiple disease portals
multiple disease outcomes
multiple disease pathogeneses
multiple disease contexts
multiple disease models
multiple disease targets
multiple disease indications
multiple disease indicators
multiple disease risks
multiple disease states
multiple disease entities
multiple disease genes
multiple disease conditions
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