Sentence examples for multiple disease loci from inspiring English sources
The genetic basis of complex diseases is expected to be highly heterogeneous, with complex interactions among multiple disease loci and environment factors.
Motivated by a schizophrenia data set, we propose a method for measuring and testing the relative entropy of a clinical phenotype, through which one can test the contribution or interaction of multiple disease loci to a clinical phenotype.
If there are multiple disease loci spread across subsets of cases, we would have had little power to detect them.
Genetic analysis of complex diseases may be complicated by many factors such as incomplete penetrance, multiple disease susceptibility loci, gene-environment interactions, and diagnostic uncertainties [ 10].
The use of resequencing microarrays for screening multiple, candidate disease loci is a promising alternative to conventional capillary sequencing.
As for the genetic aspects, progress in whole genome sequencing (for example, the 1000 Genomes Project [ 13, 14]) is beginning to provide more in-depth analyses for less frequent (but still significant), and multiple, co-existing disease loci.
The chromosome 9p21.3 region has been identified as a genetic susceptibility locus for multiple disease phenotypes including coronary artery disease, diabetes and cancer (Pasmant et al, 2011).
Analysis of the patterns of segmental sharing has the potential to map disease loci that contain multiple rare variants in a population-based linkage analysis.
Despite the fact that R-gene loci can encode multiple disease resistance specificities, it is possible that in its centre of diversity, a single aggressive pathogen can act as the major driving force to shape the evolutionary process at any such locus.
The co-segregated genomic loci can also be very large, and multiple disease genes may be present under the QTL.
However, it has been suggested that the effect of the chromosome 17q12-21 lonus on multiple diseases may reflect a more direct role on immune function rather than any tissue-specific effect [ 20, 28].
