It is clear that HRQoL results are influenced by multiple patient and disease factors, particularly age, gender, and the presence and severity of disease complications and comorbid conditions.
Asthma and its phenotypes are complex traits induced by interactions between the surrounding environment and multiple disease susceptibility genetic factors (Sengler et al. 2002).
The genetic basis of complex diseases is expected to be highly heterogeneous, with complex interactions among multiple disease loci and environment factors.
These, in turn, influence multiple risk factors and multiple disease outcomes 38, 41.
The theory of fundamental causes [ 2] posits that SES can be a cause of poor health because it can be persistent over time and it influences multiple disease outcomes, through disease risk factors and mechanisms.
In the federal government's fiscal year 2006 (beginning 1 October 2005 through 30 September 2006), AHRQ plans to fill gaps in knowledge about patient care dealing with complex conditions, such as multiple diseases and risk factors.
We here present a large-scale analysis of multiple diseases versus multiple transcription factors, with a global map of over-and under-representation of 446 transcription factors in 1010 diseases.
The difference has been growing and observable "for multiple diseases, biological and behavioral risk factors, and injuries".
With increasing attention to risk factors for multiple diseases across the life course [ 15, 16], this approach could expose potential mechanisms behind sex differences in OA and identify high-risk people in advance of disease.
Tobacco smoking is well established as a causal risk factor for multiple diseases (1).
