We performed in vivo electrophysiological studies of freely behaving Fmr1-KO mice to assess neural activity, in the form of single-unit spiking and local field potential (LFP), within the hippocampal CA1 region during multiple differentiated sleep and wake states.
The planarian epidermis is a simple, monostratified tissue that consists of clear histological organization of multiple differentiated multi-ciliated and non-ciliated cell types (Rompolas et al., 2010).
Their DSCs properties include purine-dependent asymmetric self-renewal, purine-dependent nonrandom sister chromatid segregation, long-term self-renewal, and production of multiple differentiated cell types of the skin and hair follicles.
The human cells interacted with follicle epithelium to regenerate new end bulbs and create multiple differentiated hair fibers.
Prostatic epithelium is, structurally and functionally, a highly complex tissue composed of multiple differentiated cell types, including basal, luminal, and neuroendocrine cells, along with small population of relatively undifferentiated cells generally known as "stem cells" that are endowed with self-renewal and differentiation capacities [ 26].
Human mesenchymal stem cells (hMSCs) have distinct characteristics, with a self-renewal capacity and the ability to generate multiple differentiated cell types.
Field observations from the South Fork Mountain Schist in the northern California Coast Ranges suggest that this is a zone of distributed deformation ~ 3.5 km thick, characterized by intensive microfolding, dilatant fracturing in microfold hinges, and solution-redeposition of quartz, producing multiple differentiated foliations.
When implanted into mice, the cells generated a ball of tissue containing multiple differentiated cell types, a standard test for cell pluripotency.
It coincides with the base of the remnant burrows of the fossil Trichophycus pedum and marks the first occurrence of well-developed, fairly complex metazoans (group of animals composed of multiple, differentiated cells).
Additionally, in the model moss Physcomitrella patens (Physcomitrella), multiple differentiated leaf cells facing a cut are reprogrammed to become putative chloronema apical stem cells within 48 h after dissection, without application of exogenous phytohormones14.
