Suggestions(5)
Exact(2)
Additionally, real-world searches depend on the observer's ability to find multiple different targets, whereas our observers only need to search for a target T. Future research addressing these concerns would be required to establish the value of implementing these types of screening tools in a real-world context.
However, because a single miRNA can target multiple genes and multiple miRNAs can target a single gene, miR-181b may have multiple different targets in addition to PDCD4, and PDCD4 may be regulated by different miRNAs in addition to miR-181b.
Similar(58)
Multiple different target loci can also be deconvoluted even when the same BATs have been used (because the majority of the amplicon sequenced will differ between targets).
Each miRNA has multiple different target mRNAs and each mRNA is regulated by several different miRNAs causing a very complex web of tight regulation.
In addition to accumulating link-evidence from consistent unsatisfied PEMPs, a noise-score was calculated for unsatisfied PEMPs that suggested links to multiple different target superscaffolds.
Each miRNA has the potential to regulate multiple different mRNA targets simultaneously, while a given mRNA target might similarly be targeted by multiple miRNAs (reviewed by [ 13]).
Thus, miR-10a may have multiple different mRNA targets other than BCL6, and these additional targets may also play important roles in carcinogenesis.
Since a single miRNA may have multiple different mRNA targets and conversely, a given mRNA might be targeted by multiple miRNAs, miRNAs play a central role in regulating gene expression.
To understand these results, it should be noted that this dataset may contain active compounds for multiple different molecular targets and, moreover, the heterogeneity of actives may be further increased due to the fact that the activity of compounds is measured by assays in living cell systems, where metabolism and uptake become important factor.
This is because the many subtle structural variations in the conformation of receptors that result from the binding of different ligands yield multiple subtly different targets on the receptor's surface for the binding of a variety of coregulators.
As levels of the full-length protein were decreased with mesenchymal phenotypes, we wondered about the deregulated miRNAs targeting the Dicer 3′UTR during EMT, as it was already published that this region contains multiple different miRNA target sites.
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Justyna Jupowicz-Kozak
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