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Indeed, the proteases rapidly cleaved globin peptides and intact hemoglobin at multiple different sequences.
Abastado et al. obtained multiple different sequences with "patchwork structure" after transformation of E. coli with plasmids containing a heteroduplex [22], [23].
The many thousands of identical copies of the peridinin-chlorophyll a-protein gene may undergo concerted evolution like an rRNA repeat while other highly expressed genes in L. polyedrum were found to have multiple different sequences [10].
For instance in Figure 2D frames 5 and 6 contain neurons 25-35 and 36-52, respectively which can fire in multiple different sequences within frames 5 and 6, across trials undetectably.
From the total 114 TDFs, 22 were discarded because multiple different sequences were obtained from the fragment and 11 were excluded because they had the same hit in tomato as another TDF, but at a different position.
In brief, the motifs are: (i) "index", the most prevalent sequence; (ii) "major" variant, the second most common sequence and the single most prevalent variant of the index, with at least one amino acid mutation; (iii) "minor" variants, multiple different sequences, each with an incidence (percent occurrence) less than that of the major variant; and (iv) "unique" variants, each observed only once.
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MODENA can simultaneously design multiple different RNA sequences at 1 run, whose lowest free energies range from a very stable value to a higher value near those of natural counterparts.
After the DNA sequence-dependent activation of hotspots was discovered in fission yeast, nearly two decades elapsed before the key realizations that (A) DNA site-dependent regulation is broadly conserved and (B) individual eukaryotes have multiple different DNA sequence motifs that activate hotspots.
In fission yeast (Schuchert et al. 1991; Steiner et al. 2009), in budding yeast (White et al. 1991, 1993; Fan et al. 1995), and likely in humans (Myers et al. 2008; Berg et al. 2010), multiple different DNA sequence motifs are recombinogenic, and each of those motifs has a corresponding cryptic reservoir (e.g., Table S1).
We use stochastic transitions, with a relative rate of 100/a.u. for the formation of transcriptionally active complex, so in the case of a realistic system with multiple genes, the genes are fired asynchronously and multiple trajectories with different sequences of gene activation are sampled.
However, 14-3-3 binding to multiple peptides of different sequences is evidently the first example that closely corresponds to Koshland's original induced fit hypothesis.
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multiple divergent sequences
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