The observation that these phenotypic subtypes could be established from two independent donor NP pools strongly suggests that multiple different cell phenotypes coexist in the human NP and that these can be isolated as NP subtypes and propagated as immortal cell lines.
In this study, we developed a disease gene prediction framework leveraging multiple different human phenotype data sources.
Incompletely explained events, as in Figure 4G, had a single combination of SNP alleles (e.g. GG) co-occurring with multiple different gene model phenotypes.
COPD is a heterogeneous disorder with multiple different (but related) phenotypes.
However, other genes were repeatedly observed in multiple families affected with different phenotypes (e.g. DST).
The interaction between the Blue Moon butterfly, Hypolimnas bolina, and Wolbachia has attracted interest because of the high prevalence of male-killing achieved within the species, the ecological consequences of this high prevalence, the intensity of selection on the host to suppress the infection, and the presence of multiple Wolbachia infections inducing different phenotypes.
Furthermore, these loci are characterised by multiple alleles responsible for many different phenotypes, such that we might expect the genes responsible to have undergone multiple rounds of strong positive selection.
The free-text nature of the data made searching and comparing phenotypes a challenge, since the basic concepts were expressed in multiple different ways: for example, the phenotype of heat sensitivity was described using hundreds of disparate phrases, all containing the word 'heat', and each linked to only one or a few genes.
We proposed to elucidate the gene expression phenotypes with multiple different types of genomic features together to gain better insight on the global genomic mechanism underlying cancers.
doi: 10.7554/eLife.02370 Image Changes in the sodium (horizontal axis) and potassium (vertical) conductances modify the firing behaviour of neurons Complex biological systems are able to use multiple different solutions to produce similar phenotypes or outputs.
