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Krause and colleagues [ 37] found that a single bone marrow-derived haematopoietic stem cell could give rise to cells of multiple different organs, including the lung.
Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple different organs, including the kidneys and central nervous system (CNS).
Carcinoid tumors may arise from multiple different organs and historically have been classified according to site of embryonic origin, namely foregut (gastric, bronchial), midgut (small intestine, appendix, proximal large bowel), and hindgut (distal colon, rectum, genitourinary) [ 4].
ELN has been described in multiple different organs and tissues during inflammation, including synovial tissue (ST) in rheumatoid arthritis (RA) as well as other forms of inflammatory arthritis [ 3– 5].
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Data on localisation of metastases were available on organ level, also in case of multiple locations in different organs.
Lastly, (4) NPM was found to be highly expressed in multiple cancers from different organs derived from either epithelial or non-epithelial origins.
Frequently, tumors occur at an earlier age than one would expect in the general population; often, multiple tumors of different organs develop in a particular affected family member.
Antitumor and antimetastatic properties of isRNAs were investigated in the model of HCC G-29 tumor that is accompanied by the formation of multiple metastases in different organs of mice [ 28].
Prox1 is a homeobox transcription factor that exerts multiple roles in different organs including lineage specification [ 31, 35] and maintenance of lineage identity, but its role in the mammary gland also remains unknown.
So it is not surprising to find that many in vivo and in vitro studies showed decreased levels of multiple molecules from different organs, such as nuclear factor kappa B (NF-κB), inducible nitric oxide synthase (iNOS) [ 18], caspases [ 19], reactive oxygen species [ 20], hypoxia inducible factors (HIFs) [ 21], and pro-inflammatory cytokines [ 22].
Ren et al. (2010) reported that arsenic exposure may alter DNA methylation, globally affecting the expression of multiple genes; this may explain why exposure to arsenic is associated with multiple disease outcomes in different organs.
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