Despite multiple studies using different methodologies [ 1– 11] it remains an unsettled question as to whether the multifocality represents separate primary tumors or intraglandular metastasis, or a combination of both.
The reasons for this are multiple, and include the different methodologies employed.
Furthermore, public health staff, in particular those working at the county-level CDCs, may have heavy workloads as they are involved in multiple systems which using different methodologies, terminologies, and reporting forms.
Potential biasing factors in other studies of PR expression in early breast cancer include: PR analysis at multiple, peripheral facilities using different methodologies and patient inclusion/exclusion criteria (as used in clinical trials).
Clinical laboratories currently apply different methodologies using multiple technological platforms and diagnostic expertise in a stepwise manner to detect different types of mutations.
Further still, this provides a nice segue to the next activity, which is a wholly different method of analysis, and how scientific research relies on multiple lines of evidence from different methodologies, resulting in an inherently self-correcting march toward a more detailed understanding of the natural world.
Research related to AD, PD, and other neurodegenerative diseases is highly multidisciplinary in nature, and scientists engaging in this type of research will likely employ techniques and methodologies spanning multiple different sub-disciplines of neuroscience and other biomedical sciences, which might explain the high values of betweenness centrality.
Additionally, our study augments a fourth general criterion of consistency of association (similar findings over multiple investigations using different methodology), and conforms to criteria of coherence, plausibility, analogy and experimentation as they pertain to intra-amniotic infection [8], [50].
This is considered to be less time consuming and error-prone than retrieving data from multiple national websites which may apply different methodologies for data collection [ 18].
One important observation about the figures included in biomedical publications is that they are often composed of multiple subfigures or panels, each describing different methodologies or results.
