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Despite recent advances in our understanding of grain size regulation in rice, the influence of combinations of alleles from multiple different genes remains largely unknown.
However, a convenient in vivo recombineering approach for intact large plasmids to sequentially remove multiple different genes using non-antibiotic selection methods is not described in the literature to our knowledge.
UBE3A has not been associated with Prader Willi in which multiple different genes have been implicated.
It is particularly useful in phenotypes caused by multiple different genes (e.g. evaluation of global developmental delay).
Note that, for Williams syndrome, we identified many phenotypic features that were associated with more than one candidate gene, i.e. multiple different genes all produce a similar phenotype.
Increasing evidence suggests that deletions impact affected cells by reduced dosage of multiple different genes residing on a certain chromosomal area.
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Incompletely explained events, as in Figure 4G, had a single combination of SNP alleles (e.g. GG) co-occurring with multiple different gene model phenotypes.
Where a reaction is catalysed by a single enzyme made up of multiple different gene products the mean of the fold-changes of those genes is assigned to the reaction.
Moreover, most disease traits are non-Mendelian (that is, 'complex' traits), where expression of the phenotype involves multiple different gene activities, none of which is individually required or accounts for a large fraction of heritability [ 3, 4].
Multiple different gene orders found throughout the mt genome, utility as phylogenetic markers and the unknown causes and mechanisms associated with gene duplication and subsequent retention and/or removal of sequences, calls for the determination of complete mt genomes over single genes.
Therefore, identification of a regulatory mechanism for the genes of one genomic island could represent a global mechanism that is used by that host for multiple different island genes or other genes.
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