The stem cell niche in the bone marrow is composed of multiple different cell types and hematopoiesis is probably regulated by an orchestra of different growth factors, extracellular matrix proteins, oxygen pressure and adhesion proteins [14], [24].
The degree to which single RPCs varied in their gene expression was not previously appreciated using profiling methods that employed sampling of the entire retina, which contains multiple different cell types, even at a single timepoint.
Multiple different cell types can to be simulated simultaneously.
Peripheral blood is composed of multiple different cell types and subtypes.
SHP-2 (encoded by PTPN11) is a ubiquitously expressed protein tyrosine phosphatase required for signal transduction by multiple different cell surface receptors.
The H-MRS signal arises from gray and white matter and is an ensemble average of multiple different cell types, including astrocytes, glia, and neurons.
Furthermore, perturbations in multiple different cell cycle phases can suppress a silencing defect at the S. cerevisiae silent mating type loci and telomeres (Laman et al. 1995).
We have shown that integration of ChIP datasets drawn from multiple different cell lines is a powerful technique to screen out false positive nuclear factor binding sites.
zpuf-6 + epidermal cells likely represent a branching point in the epidermal cell fate decision and can generate multiple different cell types including marginal adhesive cells (NB.22.1E and laminB ), multiciliated cells (rootletin ), and other unknown cell types.
Therefore, the current study, which focuses on insulin signaling in the adipocyte, will provide an ideal framework with which to move toward more complex signaling networks in tissues comprising multiple different cell types and multiple intercellular communication networks.
