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Linear combination of multiple diagnostic biomarkers are widely used without proper justification.
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In addition, studies based on larger size populations and using standardized protocols for controlling multiple factors that could affect the miR expression are requisite to elucidate the scope of using cardiovascular miRs as potential diagnostic biomarkers for DHD.
The BEST biomarker categories include: (a) susceptibility/risk biomarkers, (b) diagnostic biomarkers, (c) monitoring biomarkers, (d) prognostic biomarkers, (e) predictive biomarkers, (f) pharmacodynamic/response biomarkers, and (g) safety biomarkers.
Indeed, several oxidized molecules can potentially be used as diagnostic biomarkers [63].
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Lack of early diagnostic biomarkers and resistance to current therapies help explain these disappointing numbers.
Exploration of such characteristics could result in discovery of novel diagnostic biomarkers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com