The use of frameworks that allow consideration of multiple developmental factors in health system development may be particularly useful in such endeavors; FHS: Innovations for Equity has developed one such framework [ 16].
Wingless (Wnt) signaling controls multiple developmental processes in the nervous system ranging from cell determination to axon guidance and synaptogenesis [ 33, 34].
In total, 1659 genes from regions that transitioned from an active (promoter, enhancer, gene) state in EL to an inactive (repressed, heterochromatin, low signal) state in AH (Fig. 5C, top right) were strongly enriched for multiple developmental GO terms, including 'Respiratory system development' (P value 1.66 × 10−) (Fig. 5D).
These results suggest that FGFs and BMPs might influence the same regulatory systems functioning in multiple developmental areas and time points.
THBS1 is capable of activating latent TGFβ and, as alluded to previously, dysregulation of the TGFβ system affects the immune system as well as multiple developmental processes.
Furthermore, hemocyte populations are derived from progenitor hemangioblasts that give rise to multiple cell fates within the mesoderm of both developmental systems [3].
This supports our original hypothesis that prenatal effects of cocaine and their inter-individual variability may involve the integrating circadian system, potentially causing desynchronization of multiple developmental events.
First, between proponents of monism about heredity (gene-centric views), holism about heredity (Developmental Systems Theory), and those stressing the role of multiple systems of inheritance.
The gene ontology (GO) analysis of the 580 genes downregulated in Twin-DS-iPSCs revealed significant enrichment for genes involved in multiple developmental processes including embryonic development and morphogenesis, organ development and morphogenesis and system development.
