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Fate specification and differentiation requires the interplay of multiple developmental signals.
The core Hippo components therefore respond to and coordinate multiple developmental signals [ 16- 18] (recently reviewed by [ 19]).
Phylogenetic analysis reveals that the upstream regulators and downstream targets have more significantly evolved than the core components, indicating that the Hippo pathway has integrated multiple developmental signals during evolution.
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Genes targeted by those differentially expressed miRNAs (i.e. miR156, miR164, miR167, miR397, miR1861, and miR1867) were recognized to play roles in multiple developmental and signaling pathways related to plant hormone homeostasis and starch accumulation.
Wingless (Wnt) signaling controls multiple developmental processes in the nervous system ranging from cell determination to axon guidance and synaptogenesis [ 33, 34].
BRI1-Associated Receptor Kinase 1 (BAK1) is a leucine-rich repeat serine/threonine receptor-like kinase (LRR-RLK) that is involved in multiple developmental pathways, such as brassinosteroid (BR) signaling, plant immunity and cell death control in plants.
The highly conserved N signalling pathway participates in multiple developmental processes that entail cell fate determination in both invertebrates and higher organisms.
There is a wealth of evidence indicating that FGF signalling is involved in regulating multiple developmental processes before and during amphibian gastrulation [1], [35].
Wnt signaling has been implicated at multiple developmental stages of the neural crest [ 18- 24].
RAP2.4 acted at or downstream of a converging point of light and ethylene signaling pathways, and it coordinately regulated multiple developmental processes and stress responses [ 63].
Together, these results indicate that the TDIF ligand-PXY/TDR signal transduction pathway is an important regulator of multiple developmental processes [ 19].
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