This finding expands the repertoire of genetic interactions involving Fgf8 that alter facial development to include Foxc1, Fuz and Tfap2a, suggesting that Fgf8 might act in concert with multiple developmental regulatory programs to modify face formation (Inman et al., 2013; Tabler et al., 2013).
We found the naive receptor in unstimulated cells bound to an extensive array of gene clusters with functions in regulation of gene expression, differentiation, and pattern specification, connecting multiple morphogenetic and developmental programs.
A further study concluded that multiple cell type-specific developmental programs, including those of amacrine, horizontal, photoreceptor and progenitor cells, are co-expressed in individual human retinoblastoma cells (McEvoy et al, 2011).
Developmental programs, controlled by multiple cell-intrinsic and –extrinsic cues, establish unique patterns of connectivity for the diverse neuronal subtypes located in different layers.
Throughout the insect life cycle, the steroid hormone 20-hydroxyecdysone (20E) coordinates multiple developmental events by eliciting a complex genetic program via a heterodimeric nuclear receptor composed of the ecdysone receptor (EcR) and ultraspiracle proteins (USP).
This unique versatility enables multiple plant biological processes to be controlled, including developmental programs and stress responses.
Building the vertebrate head relies on complex developmental programs involving molecular cross-talks between multiple cell types belonging to the three germ layers [1].
This coordinated and environmentally responsive program of meristematic differentiation and tissue patterning involves multiple developmental processes with interacting regulatory mechanisms (reviewed in [ 7, 8, 4]).
Diversification in regulatory programs is an indication of the ability of an organism to respond to multiple developmental and environmental cues.
Nascar has no particular developmental programs to attract and train minority drivers.
