This study considers total cost minimisation of multiple plausible design choices and eight candidate antisolvents for the continuous recovery of artemisinin (a potent antimalarial Active Pharmaceutical Ingredient/API) via continuous crystallisation, with simultaneous evaluation of process mass and environmental efficiency via the E-factor (an established green chemistry metric).
The program admits complex tables with up to an indeterminate number of mating types (only limited by the computer memory and speed) and different choice designs: multiple choice, male choice, female choice or no choice designs.
These could be accomplished in multiple ways through experimental design choices, selection of variables to measure, and how carefully measurements are made.
Such elements include the measurement of relevant clinical outcomes, definition of endpoints, effect sizes, multiple inferences, and principal trial design choices such as placebo- or active-controlled trials.
In the framework of the JT-60SA project, the Toroidal Field (TF) coils design has required to address reliably the choice between multiple design options and to calculate the temperature margin criterion for the superconductor.
A second approach that can be particularly fruitful is to look at multiple modes of reconfiguration and organization design choices in combination.
Generally, design choices take place according to multiple criteria: some of them may be contradictory.
This study uses data collected from multiple sites to examine the implications of product diversity for costing system design choices.
Moreover, design choices take place in an uncertain context and according to multiple criteria, some of which may be contradictory.
"The exhibition layout references domestic space through interior design choices and feng shui principles," she adds, giving a generous shortcut to an exhibition that easily requires multiple viewings.
