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VBM analyses are based on statistical significance thresholding, where thresholds are estimated using random field theory to correct for multiple dependent comparisons [Worsley et al., 1996].
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Based on the multiple-pathway-dependent comparison analysis (MPDCA), it may lead to the conclusion that jasminoidin possibly contributes more important pharmacological effect in the combined treatment as jasminoidin regulated 80% of the pathways that the combination group mediated.
Table 7 Result of multiple comparisons Dependent Variable (I) where (J) where Mean Difference (I-J) Std.
If significant differences between the means were found, we used a post-hoc Bonferroni test for multiple comparisons of dependent means.
Bonferroni-Holm- corrections for multiple comparisons adjusted for dependent measurements have been performed for all correlations (k = 10) [32].
When repeated measures ANOVA detected statistical significance, it was followed by a Tukey multiple comparisons post-test for dependent samples to correct for multiple measurements.
This decision was based on the fact that in addition to pre-specifying these analyses, the multiple-type outcomes are inter-dependent and conventional correction for multiple comparisons would be overly conservative.
The dependent variable corresponding to the taxonomy of the organizations will be dichotomous or multinomial, depending on the focus of analysis (single models vs multiple models comparisons).
After accounting for multiple comparisons (20 tests per dependent variable) with a Bonferroni correction, P ≤ 0.003 was considered significant.
However, after accounting for multiple comparisons (17 tests per dependent variable) with a Bonferroni correction, P ≤ 0.003 was considered significant (Gomez and Gomez 1984; Morzillo et al. 2007; Paulson 2008; Tadesse and Teketay 2017).
For multiple comparisons, a Bonferroni multiple comparisons correction was used.
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