Sentence examples for multiple deletions that from inspiring English sources

The β-globin gene locus lies between two olfactory receptor (OR) gene clusters [1] and is subject to multiple deletions that cause β-thalassemia, a transfusion-dependent anemia.

These regions often had indications of multiple deletions that lacked spanning reads to define their end points.

Thus, the Apo-A gene has undergone multiple deletions that might affect its physiologic function, which is in contrast to all other known apolipoprotein genes [ 30, 31].

The MDLT may possibly be instances of multiple deletions that are specifically retained by a single species or cases of intra-group gene transfers.

Evolving from a tetraploid to a diploid state includes not only accumulation of mutations, but also random rearrangements and recombinations as exemplified by the multiple deletions that have occurred in the Atlantic salmon IA and IB regions.

These genomic screens revealed the presence of only eight remnant exons containing both frameshifting indels and multiple stop codons (Fig.  3) in this region and multiple large genomic deletions that have led to the deletion of several exons.

Only insertions or deletions that involve multiples of three bases are retained in the GC-rich stretch of monocot ATG6s because they do not result in translational frame shifts.

In detail, there is a cluster for all strains having spacer 0, for all strains having spacer 1, and for all strains having spacer 2. The terminal branch leading to angola is much longer for NJ U, since multiple deletions are needed that can be explained by only one event under the fragment loss model.

Deletions that did not affect growth were integrated to construct multiple-deletion strains (Supplementary Fig. S2).

In this study we present evidence for the first time that multiple deletions of mtDNA cause respiratory deficiency within neurons as a result of clonal expansion in MS. There were strikingly more neurons lacking complex IV and with complex II activity (respiratory-deficient) in SPMS cases compared with aged controls.

As a single-deletion event is more likely than multiple deletions events, it is likely that this inversion occurred in the CHM1 genome but may not be the more common allelic form in the human population.