Sentence examples similar to multiple day dosing from inspiring English sources

This is demonstrated in multiple rodent models using a single dose, multiple-day dosing or a multiple-day BID dosing regimen.

One possible explanation for these side effects are the multiple peaks and troughs in plasma concentration levels with the multiple dose per day dosing schedule required for mean therapeutic plasma levels.

Dose varied from single dose to multiple day administration.

Single dose prophylaxis appears to be an excellent regimen compared to multiple day regimens independent of urgency of procedure [ 2- 6].

In most studies gabapentin was administered one to two hours preoperatively, but in three studies [ 31, 34, 36] a multiple (repeat) dosing regimen initiated the day before surgery was investigated.

AChE levels for detailed pharmacodynamic (PD) analysis were also determined by the method of Ellman et al. [ 12] in frozen whole blood samples taken before the first dose of the multiple dose phase (day 1) and then again on day 12 before the last dose of the multiple dose phase, 4 h later and then again on day 21 (9 days after the last dose).

The 3-day dosing experiments indicates that the phase delays from multiple days of dosing are additive.

In humans MEM 1414 has been studied in 5 clinical trials, in single ascending dose studies ranging from 15 mg to 1000 mg and in a 14 day multiple ascending dose trial ranging from 50 mg to 400 mg.

The impact on leading a normal life was attributed both to multiple dosing and to fluctuations in mental/physical energy over the day as multiple daily dosing with hydrocortisone/cortisone acetate causes peaks and low trough values in-between dosing occasions.

However, some of the current oral formulations of 5-ASAs are inconvenient for patients because patients require multiple doses per day and/or multiple tablets per dose.

These trials were performed with two different GKAs: RO-4389620 (cpd M or piragliatin) from Hoffmann La-Roche in a 5.5-day multiple ascending dose study and ARRY 403 from Array Biopharma in a 1-day single ascending dose study.