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From a research standpoint, multiple database analyses are only rarely exploited for signal detection: we believe that the use of different SRSs represents an added value in the current era of drug safety research, where several consortia have been created to fully assess drug-related risks in the post-marketing setting.
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Both were database analyses.
MJ designed and performed the database analyses.
The usual recommendation for meta-analyses is to use multiple databases.
Six of the seven proteomics analyses mapped their spectra to multiple databases of predicted proteins, including UniProtKB/SwissProt (34), UniProtKB/TrEMBL (34), IPI (38), H-InvDB (39) and RefSeq (30) in addition to Ensembl/GENCODE.
The highly sensitive search strategy, searching multiple databases and clinicaltrials.gov, searching publications written in any language, and performing subgroup analyses and sensitivity analyses, provides strength and rigor for our meta-analysis.
And third, we compared our method with literature searches of the published meta-analyses that often combined separate searches in multiple databases, supplemented with the screening of references lists, conference abstracts and grey literature, and the consultation of experts.
Comparative analyses were performed with cluster sequences as queries versus multiple databases including C. elegans Wormpep v.203 protein database [ 46].
As multiple databases containing RInChI become available, this common label will enable consistent and straightforward analyses of diverse data.
Where the same genome was obtained from multiple databases, duplicates were culled such that only a single copy was used in analyses.
However, under the UID project, multiple databases would be unified.
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