Sentence examples for multiple cytokines that from inspiring English sources
When challenged with vaccinia virus (VV) expressing HIV-1 Gag, they elicited a potent Gag-specific recall response characterized by CD8+ T cells expressing multiple cytokines that were capable of specifically lysing Gag-pulsed target cells.
In addition, effector CD4 and CD8 cells both provide cellular immune responses and can secrete multiple cytokines that reflect the quality of the effector-cell compartment of the immune responses.
There are contradictory reports regarding whether STAT3 and its phosphorylation can directly regulate TNF-α production in macrophages following LPS stimulation, which is at least partially due to the production of multiple cytokines that might crosstalk.
In contrast, we show that senescent VSMCs perpetually secrete multiple cytokines that drive inflammation and myeloid cell recruitment.
Upon stimulation, iNKT cells can rapidly produce multiple cytokines that direct the immune response towards a pro-inflammatory (Th1 or Th17) or an anti-inflammatory (Th2) bias [ 12]. iNKT cells are implicated in the pathogenesis of various obesity-related diseases, including psoriasis [ 13], cancer [ 14, 15] and arthritis [ 16, 17].
Similar treatment with multiple cytokines found that IL-10 remained the only cytokine that significantly downregulated the HLA-DR expression on CD14+ monocytes.
RPE cells play an important immunomodulatory role in the outer retina, in part by producing and secreting multiple cytokines [36] that contribute to the environment of immune privilege in the subretinal space [13].
High expression of multiple cytokines suggests that tumour angiogenesis is activated by multiple pathways.
HSC expansion requires multiple interacting cytokines that influence growth, differentiation and apoptosis, making this a very complex system to optimize.
Bone resorption is tightly and dynamically regulated by multiple mediators, including cytokines that act directly on osteoclasts and their precursors, or indirectly by modulating osteoblast lineage cells that in turn regulate osteoclast differentiation.
Our meta-analysis of publicly available microarray datasets revealed that microarrays failed to detect multiple cytokine genes that have been linked to various human kidney conditions.
