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5, 6 Skin malignancies linked to arsenic include squamous cell carcinomas, basal cell carcinomas, Merkel cell carcinoma, intraepidermal carcinomas (Bowen disease), 7, 8 and multiple cutaneous malignancies.
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We, here, give an overview on currently known serologic and newer immunohistochemical biomarker molecules in the most common cutaneous malignancies, malignant melanoma, squamous cell carcinoma and cutaneous lymphoma, particularly emphasizing their prognostic and predictive significance.
Cutaneous malignancies, especially malignant melanoma, exhibit great genetic heterogeneity.
The incidence and diagnosis of cutaneous malignancies are steadily rising.
Patients with cutaneous malignancies often require multidisciplinary care.
This approach is applicable for the treatment of cutaneous malignancies of the lower extremities.
Ultraviolet (UV) solar radiation produces harmful effects on the skin including sunburn, local immunosuppression, skin photoaging, and cutaneous malignancies.
Despite a high frequency in some benign skin disorders, FGFR3 mutations have not been reported in cutaneous malignancies.
We also review the literature on CIE-associated skin cancers and discuss the possible contribution of ichthyosis to the risk of cutaneous malignancies.
Histopathologic features of multiple cutaneous squamous cell carcinomas of the lower extremity.
Mohs micrographic surgery has the highest cure rates, spares the maximal amount of normal tissue, and is cost-effective for the treatment of cutaneous malignancies.
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