Figure 9 gives further support to the notion that, being an intrinsically disordered hub, p53 is located at the middle of a large and well-developed network of protein-protein interactions, serving as a crucial linker that connects multiple important pathways.
In addition, these three pathways play multiple, crucial roles in the primordium of the lateral line (reviewed in Aman and Piotrowski, 2009; Ma and Raible, 2009; Chitnis et al., 2012).
Recent studies have reported that miRNA-205 is frequently deregulated in multiple tumour entities and involved in various crucial pathways, such as cell proliferation, apoptosis and angiogenesis, by mediating the expression of multiple oncogenes (figure 7).
This permits an assessment of N-glycan structures isolated at multiple crucial points along the N-glycan remodeling pathway as it would occur in the Golgi.
By enabling dialogue, Global Dignity Day opens the gate to those crucial pathways.
Also, the run D really got itself together, stuffing the Cards on multiple crucial plays.
Approaches in which a crucial pathway is targeted at multiple points might also permit effective targeting of the pathway at lower concentrations of each individual drug, and therefore with reduced toxicity to the patient.
Thus, in theory, a single DCN molecule could simultaneously sequester multiple important mediators of tumor growth and antagonize multiple signaling pathways crucial for tumor growth and progression [ 36].
Art is a crucial pathway because it works through emotion and the senses, and because it provokes without prescribing". .
But it will provide a crucial pathway to dealing with nearly half of the world's energy carbon emissions.
