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We here used a multiple crossover design to investigate the effects of neonatal (postnatal day 7) ethanol treatment (2.5 g/kg b.i.d., dissolved in saline), subchronic peripubertal (postnatal days 40 65) ethanol treatment (1.0 g/kg, dissolved in saline) and the combination of both on the performance of adult Wistar rats in a variety of behavioral tasks.
On the other hand, each subject served as their own control, and the multiple crossover design of the study certainly enhanced both the internal validity and the reliability of these data.
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Randomization of multiple wards in a crossover design is probably to be preferred.
Presented here is the development a semi-rational protein engineering approach that uses information from protein structure coupled with established DNA manipulation techniques to design and create multiple crossover libraries from non-homologous genes.
This was a Phase I, multiple-dose, fasting, randomized, open-label, crossover design study in healthy adult volunteers (n=36).
The pharmacokinetic study was conducted in 12 healthy subjects administered with multiple doses of 100 mg of diclofenac in a crossover design.
Furthermore, we design a hybrid multi-objective genetic algorithm that integrates multiple crossover operators and linear programming techniques to solve the proposed problem.
Design: Prospective, single crossover design.
Design: Counter-balanced crossover design.
pastures in a crossover design.
A within-subject, crossover design was employed.
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