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Hence, we concluded that the occurrence of dramatic MS alterations in 3p chromosome multiple critical regions could be a crucial underlying mechanism, which proceeded the lung toxicity in air pollution PM-exposed target L132 cells.
The occurrence of MicroSatellite (MS) alterations in 3p multiple critical regions (i.e. 3p14.1, 3p14.2, 3p14.3, 3p21.1, 3p21.31, and 3p21.32) identified as showing frequent allelic losses in benign or malignant lung diseases, was also studied in Dunkerque City's PM2.5-exposed L132 cells.
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To address the issue, this paper proposes a Generalized Reliability Importance Measure (GRIM) that can deal with multiple critical failure regions, large curvatures of limit-state surfaces and the correlation between the input random variables.
In particular, any elastic foundation (discrete or distributed) leads to multiple critical speeds and a single region of divergence instability above the first critical speed, whereas the unsupported string has one critical speed and is stable at all supercritical speeds.
WHS is caused by the partial deletion of the short arm of chromosome 4, which harbours two overlapping critical regions (WHSCR-1 and WHSCR-2) consisting of multiple genes.
In this approach, invisible microbes play multiple critical roles.
This is described below for a single critical bus; further work will consider multiple critical buses.
"If we didn't act now, we risked losing this critical region forever".
This critical region is magnified in Figure 11(b).
It is therefore not located in the critical region.
It has so far extracted two virtually complete cores from a critical region of Antarctica.
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