Our data therefore reveal multiple critical functions for Erk5 in controlling ESC identity.
Lipids constitute essential components of the cell and carry out multiple critical functions from building blocks of biological membranes to regulatory roles in signal transduction, organellar biogenesis, energy storage, and virulence.
DNA methylation is an epigenetic modification that is widely employed in eukaryotes, including plants, fungi and animals, and serves multiple critical functions [ 1- 3].
The CXCR4 chemokine receptor is a seven transmembrane G-protein coupled receptor with multiple critical functions in both the normal and pathological states, having a sole natural ligand (CXCL12).
Integration of multiple critical software functions in a single embedded platform requires domain partitioning.
Mitochondria elicit multiple critical cellular functions including (1) energy generation via the electron transport chain, (2) heme synthesis, (3) iron sulfur cluster biogenesis and (4) iron metabolism [ 12].
Owing to multiple and critical functions played by mtHsp70, the PD variants are expected to contribute significantly toward PD, where mitochondrial dysfunction is an established feature.
QPCR results demonstrate statistically significant down-regulation of multiple genes with critical functions in immune system development and, by inference, immunity at 24 hpf.
It has been shown that programmed necrosis exerts critical functions in multiple patho-physiological settings, e.g. the regulation of bone growth, ovulation, negative selection of lymphocytes [ 28], pancreatitis [ 22, 29], epilepsy, ischemia reperfusion injury, Parkinson's, Huntington's and Alzheimer's disease, and cell destruction by Salmonella, Shigella, HIV and vaccinia virus [ 4, 28, 30, 31].
DOI: http://dx.doi.org/10.7554/eLife.02872.002 The retinoblastoma tumor suppressor protein (Rb) functions to regulate multiple critical cellular activities, including the late G1 restriction point, the DNA damage response checkpoint, cell cycle exit, and differentiation (Burkhart and Sage, 2008; Paternot et al., 2010; Henley and Dick, 2012; Johnson and Skotheim, 2013).
Disulfide bonds, which play multiple critical roles in protein stability and function, are often abundantly present in secreted proteins.
