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Many of them are also known to be involved in multiple critical cellular events, including protein translation and ribosomal biogenesis.
Mitochondria elicit multiple critical cellular functions including (1) energy generation via the electron transport chain, (2) heme synthesis, (3) iron sulfur cluster biogenesis and (4) iron metabolism [ 12].
However the discussion/scientific impact only corroborate previous expression studies on the role of multiple critical cellular pathways such as anti-apoptosis, cell proliferation, and signalling pathways, that were found to be loosely associated with PKC-b function.
DOI: http://dx.doi.org/10.7554/eLife.02872.002 The retinoblastoma tumor suppressor protein (Rb) functions to regulate multiple critical cellular activities, including the late G1 restriction point, the DNA damage response checkpoint, cell cycle exit, and differentiation (Burkhart and Sage, 2008; Paternot et al., 2010; Henley and Dick, 2012; Johnson and Skotheim, 2013).
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Genes with critical cellular functions are frequently regulated through a circuit involving multiple regulatory elements that are brought within physical proximity by DNA folding.
Thus, through its multiple interactions with signaling molecules, scaffolding proteins and cell polarity proteins, CagA disregulates critical cellular functions to enter the sub-epithelial tissues which also leads to inflammation and eventually to cancer (Hatakeyama 2004).
MiRNAs are known to play multiple roles in carcinogenesis, immune responses and organ development [6], [7], and have been implicated in many critical cellular processes, including apoptosis, proliferation, and differentiation [8].
MiRNAs are known to play multiple roles in organ development, carcinogenesis, and immune responses [ 16, 17], and have been implicated in many critical cellular processes, including apoptosis, proliferation, and differentiation [ 18].
It is now ascertained that prostate cancer emerges from multiple spontaneous and/or inherited alterations that induce changes in expression patterns of genes and proteins that function in complex networks controlling critical cellular events.
And, could condensates just be biophysical artifacts with no real role, rather than critical cellular structures?
Fungicides kill pathogenic or parasitic fungi by disrupting their critical cellular processes.
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