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P values were adjusted for multiple correlated tests (PACT).
We used global tests of main effects and treatment interactions, adjusting the P-values for multiple correlated tests.
As mentioned in Leek and Storey (2007), q-values can be misleading when applied to multiple correlated tests.
To avoid the burden of multiple correlated tests, we used only genotyped markers and discarded the pseudomarkers used for single-locus interval mapping.
In order to maintain the family-wise Type 1 error at 0.05 over the multiple (correlated) tests, we set the critical alpha at a conservative 0.01.
To account for the correlated tests from the determination of a genetic model for a given SNP and for the multiple correlated tests from the SNPs within each gene region, we performed a P-value adjustment for correlated tests.
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This exploratory approach, however, is known to cause inflation of a type I error because it conducts multiple correlated testing [ 36- 38].
It should be mentioned that all local spatial statistics are complicated by the presence of global spatial autocorrelation and multiple and correlated tests (Boots 2002).
This will involve: conducting conditional tests to identify the causal genetic variant among multiple correlated signals; testing whether the effect of PTSD genetic risk variants is moderated by age of first trauma, trauma type, and trauma severity; and exploring gene-gene interactions using a novel gene-based statistical approach.
Permutation tests are often employed to adjust groups of correlated tests for multiple testing, since conventional methods such as Bonferroni correction are overly conservative when tests are correlated (Conneely & Boehnke, 2007).
Inouye et al. (15) showed that association testing of multiple correlated phenotypes offers better power than univariate analysis of single traits.
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multiple standardised tests
multiple correlated testing
multiple correlated pollutants
multiple correlated processes
multiple correlated responses
multiple correlated SNPs
multiple correlated markers
multiple correlated descriptors
multiple correlated distributions
multiple correlated VMs
multiple correlated exposures
multiple correlated features
multiple correlated signals
multiple correlated items
multiple correlated traits
multiple correlated phenotypes
multiple correlated risks
multiple correlated sources
multiple standardized tests
multiple correlated factors
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