Exact(3)
In particular, there is a need for a comprehensive study describing the population genetics of multiple control populations and a need for agreement on HapMap SNPs or another maximally informative set of pan-European SNP markers, bearing in mind that the SNPs are markers for what may prove to be more complex sets of causative genetic variants.
Future studies reporting acute and post-acute mortality, adjusted for confounding, should incorporate multiple control populations to help us answer this question.
This weakness is most evident when comparisons are made to multiple control populations, both within and between subjects.
Similar(57)
For example, genetic changes can be detected in CTCs, including abnormal telomerase activity (Soria et al, 1999), allelic loss and/or amplification of multiple oncogenes not seen in normal control populations (Austrup et al, 2000), and aneuploid changes in cellular chromosome content based upon FISH analysis similar to those seen in the primary tumour (Fehm et al, 2002).
So multiple control efforts may be necessary.
Multiple control points are introduced.
You can drop multiple control points.
When multiple control groups were used in a study we only included the control group that was most representative of the source population for meta-analysis.
The matched cohort design allows multiple controls from the general population to be sampled for each case, which allows investigators to identify population risks and baseline rates of events of interest.
The presence of multiple markers was not detected in the control population.
In the case of multiple studies apparently based on the same case or control population, we included only the study with the largest number of participants.
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