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We describe here an Iranian family with multiple consanguinity loops with over 30 individuals with PKD.
The third autosomal recessive PD gene, PARK7 (or DJ-1; MIM 602533) was identified by homozygosity mapping in an extended Dutch family with multiple consanguinity loops [ Bonifati et al., 2003; van Duijn et al., 2001] (Table 1 and Fig. 5).
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A three-generation family of Turkish origin with multiple loops of consanguinity demonstrating autosomal recessive inheritance was recruited (Supplementary Fig. 1).
Bifurcation analyses on feedback loops indicate that multiple feedback loops are coordinated to modulate sporulation efficiency.
Hypothalamic inflammation influences the set points of multiple homeostatic loops.
The Arabidopsis circadian clock is composed of multiple feedback loops.
The original loop is one part of interconnected multiple feedback loops that contain the morning- and evening-expressed clock proteins.
Among these patients, 57.75% had only single tortuous loops, while in 26.76% multiple tortuous loops were observed.
It is known that multiple feedback loops regulate gastric acid secretion.
Moreover, the context-dependent roles of miRNAs in the metastatic cascade often involve multiple regulatory loops.
Therefore, in this study, only the presence of multiple tortuous loops was classified as abnormal.
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