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The solution-state NMR spectra for the monometallic titanium piperazine salan complexes Ti(1 5)(OiPr)2 show that the complexes adopt multiple conformations in solution, unlike the solid-state structures which all showed the β-cis conformation.
These observations suggest that the oxime-pyridinium ring is rather mobile (adopting multiple conformations) in the active-site gorge.
The electron density suggested that the side chains of few protein residues existed in multiple conformations in the crystal.
The C and N terminal and nearby residues of PG-1 sample multiple conformations in the solution NMR structures[36] and the DLPC bilayer MD simulation [15].
At neutral pH, the spectroscopic data suggested the presence of multiple conformations in equilibrium.
Thus, the pre-integrated TMD/Sec61α complex likely samples multiple conformations in the absence of CT8.
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Within the hybrid PT/SA scheme, a composite system with multiple conformations is evolving in parallel on a temperature ladder with various transition step sizes.
These results suggest that GDP-bound ATLs may adopt multiple conformations and the in vitro fusion activity of ATL cannot be achieved by a simple collection of functional domains.
It illustrates that to a unique sequence corresponds multiple conformations functionally suitable, in good agreement with the energy landscape theory [33], [34], [35].
These EPR measurements indicate that the ligand binding loops of these TBDTs exist in multiple conformations and that these conformations are in equilibrium.
Structures of the maltose transporter were obtained in multiple conformations and a single binding site in the transmembrane domain is identified.
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