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These results suggest that GDP-bound ATLs may adopt multiple conformations and the in vitro fusion activity of ATL cannot be achieved by a simple collection of functional domains.
However, this fixed-backbone approximation introduces its own special challenges for enzyme design and it contrasts with an emerging picture of natural enzymes as dynamic ensembles with multiple conformations and motions throughout a reaction cycle.
Each docking program reported multiple conformations and associated binding energies.
Multiple conformations and orientations of each ligand were docked into the kinase binding sites using DOCK 3.5.54.
Structures of the maltose transporter were obtained in multiple conformations and a single binding site in the transmembrane domain is identified.
These EPR measurements indicate that the ligand binding loops of these TBDTs exist in multiple conformations and that these conformations are in equilibrium.
Similar(48)
Third, multiple conformations are identified and clustered from simulation data and further projected on a three-dimensional globe specifying protein orientations and interacting energies.
For particles with multiple conformations, inaccurate alignments and orientation parameters will yield an averaged map with diminished resolution and smeared density.
There are multiple conformations of plasminogen and the protein populates the various forms.
In contrast, NMR spectra of unstripped Na-FAR-1 in solution, like those of other FAR proteins we have tested, were characterized by broad signal peaks indicative of multiple conformations and/or conformational exchange.
Consistent with these biochemical data, the WT-Merlin displays multiple conformations in solution, and the substitution of Ala585 with Trp converts Merlin into a highly homogeneous monomer conformation as shown by analytical ultracentrifugation analysis.
More suggestions(15)
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multiple surgeries and
multiple hospitals and
multiple voices and
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multiple arms and
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