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Consistent with this notion, the B factors in this region are typically high across crystal structures of PA determined to date, suggesting that this residue may be able to sample multiple conformational environments.
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These results suggest the necessity of multiple conformational states in the reaction.
These fluctuations interconvert multiple conformational states that are separated by small energetic barriers.
As a result, the ensemble structures corresponding to multiple conformational states are required to fully depict protein dynamics.
We here introduce an algorithm capable of designing groups self-assembling of nucleic acid molecules with multiple conformational states.
Thereby, integrins adopt multiple conformational and functional states that control ligand binding affinity and linkage to cytosolic/cytoskeletal proteins.
Therefore, it is appropriate to represent a flexible multi-domain protein by an ensemble of structures containing multiple conformational states (Bernadó and Blackledge, 2010).
We propose that multiple conformational changes of Smo are required for ciliary translocation and subsequent pathway activation.
However, Kamerlin et al. did not examine free energies of possible multiple conformational minima.
Such multiple conformational transitions may be required for ACP to accommodate fatty acids of various lengths (12, 14).
However, multiple conformational changes are seen throughout the rest of each domain in response to bound nucleotide.
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