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From the opposite perspective, there may be no "permissive" temperature for higher-order septin assembly if more than one septin subunit is mutated, imposing multiple conformational constraints at distinct septin septin interfaces within or between heterooligomers.
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This was attributed to conformational constraints imposed to the biomacromolecule entrapped in the polymeric matrix.
As a result, the ensemble structures corresponding to multiple conformational states are required to fully depict protein dynamics.
These results suggest the necessity of multiple conformational states in the reaction.
These fluctuations interconvert multiple conformational states that are separated by small energetic barriers.
This work mentions that appropriate conformational constraints might be a useful optimizing tool for this unique class of anticancer compounds.
The target compounds contained fused 1,4-diazepanones incorporated into a peptide backbone and served as conformational constraints.
Therefore, it is appropriate to represent a flexible multi-domain protein by an ensemble of structures containing multiple conformational states (Bernadó and Blackledge, 2010).
We here introduce an algorithm capable of designing groups self-assembling of nucleic acid molecules with multiple conformational states.
Thereby, integrins adopt multiple conformational and functional states that control ligand binding affinity and linkage to cytosolic/cytoskeletal proteins.
However, when the A chains are grafted to a surface, only limited amounts of B can be solubilized into this grafted shell due to the conformational constraints.
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