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Of our 28 CDR-lengths, 15 have multiple conformational clusters, including 10 for which the Chothia analysis had only one canonical class.
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Topics include fundamental processes of RNA, such as structural assemblies (hierarchical folding, multiple conformational states and their clustering), RNA motifs, and chemical reactivity of RNA, as used for structural prediction and functional inference.
Most of the structures in the data set belong to two conformational clusters.
As a result, the ensemble structures corresponding to multiple conformational states are required to fully depict protein dynamics.
These results suggest the necessity of multiple conformational states in the reaction.
These fluctuations interconvert multiple conformational states that are separated by small energetic barriers.
Therefore, it is appropriate to represent a flexible multi-domain protein by an ensemble of structures containing multiple conformational states (Bernadó and Blackledge, 2010).
We here introduce an algorithm capable of designing groups self-assembling of nucleic acid molecules with multiple conformational states.
Thereby, integrins adopt multiple conformational and functional states that control ligand binding affinity and linkage to cytosolic/cytoskeletal proteins.
Clusters were scored and the lowest energy conformational clusters analyzed.
The conformational clusters were labeled according to definitions given in Figures 7 and 8, respectively.
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