Sentence examples for multiple conformational changes from inspiring English sources
A 3.5 Å crystal structure of the 80S eukaryotic ribosome from S. cerevisiae in complex with AglA was obtained, revealing multiple conformational changes of the nucleotide bases in the ribosome accompanying the binding of AglA.
We propose that multiple conformational changes of Smo are required for ciliary translocation and subsequent pathway activation.
His-HDX-MS was used to probe the microenvironment of histidine residues of E. coli dihydrofolate reductase (DHFR), an enzyme proposed to undergo multiple conformational changes during catalysis.
However, multiple conformational changes are seen throughout the rest of each domain in response to bound nucleotide.
This result is consistent with the concept of multiple conformational changes between inactive and fully active tBid and Bax.
Activation of Bax and Bak during apoptosis involves multiple conformational changes that are accompanied by their mitochondrial intramembranous homooligomerization [ 6].
For example, the first step of the actomyosin functional cycle (Fig. 2) may include the formation of the ATP-binding pocket by multiple local conformational changes (Dominguez et al. 1998; Coureux et al. 2003).
It is believed that envelope glycoprotein undergoes multiple programmed conformational changes during cellular receptor interaction [53], [54], [55].
The results obtained are consistent with transporters undergoing multiple substrate-induced conformational changes, which allow interaction with different accessory proteins to trigger specific downstream events.
In the previous examples, a macroscopic change was induced by the sum of multiple, relatively uncontrolled conformational changes in a polymeric network; that is, the observed change is not an inbuilt feature of the molecular components.
We made systematic improvements, beginning with single poses from docking, then including multiple poses, additional protein conformational changes, and using an improved charge model.
