In order to examine genealogical concordance, multiple loci were examined.
It is for precisely this reason that we have previously used concordance between multiple methods to establish the core classes: the identification of stable clusters through multiple methods forms a basis of methodological validation (Soria et al, 2010).
O'Rawe J, Jiang T, Sun G, Wu Y, Wang W, Hu J, et al. Low concordance of multiple variant-calling pipelines: practical implications for exome and genome sequencing.
Conclusions: Both devices demonstrated statistically significant pain reduction in comparison to baseline, with concordance across multiple indices.
Despite this, the human results are in concordance with multiple animal studies [5, 49, 54 57, 61, 62] that support the clinical data [50] that P-APRV may be used to reduce the incidence of acute respiratory distress syndrome (ARDS) more effectively than conventional LTV ventilation applied early or after the onset of ARDS.
However, the significant concordance across multiple provides independent validation.
Concordance across multiple data types (e.g., genetic, morphological and geographic) is, of course, desirable (revised by [ 37]).
3. O'Rawe, J. et al. Low concordance of multiple variant-‐calling pipelines: practical implications for exome and genome sequencing.
In concordance with multiple lines of evidence suggesting these events were rare and transient, single-molecule RNA FISH showed that transcription was limited.
Eleven out of 30 genes (SLC26A3, CASP9, VIM, LGALS4, SRI, UGP2, LGALS3, TPM1, TUBB, MAP2K7 and CRABP2) showed good concordance with multiple microarray expression studies.
As a recent study has shown low concordance between multiple variant-calling pipelines [ 40], we decided to increase the level of confidence by using two variant-calling pipelines.
