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It offers multiple, concerted, bonding sites for heavy metals and forms a stable metal ligand precipitate.
This tubulation is accomplished by multiple concerted interactions with the membrane.
Hence, one way to prioritize is to identify genes with evidence of multiple concerted disruption.
Thus, the structure of the APY EphA4 complex suggests that APY can effectively inhibit EphA4 signaling through multiple concerted mechanisms.
Addressing these could effectively impact the epidemic if it is done through multiple concerted efforts and at scale.
In this study, we have developed a stepwise gene selection strategy to identify multiple concerted disruptions using an integrative genomics approach.
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These four points guide the successful application of the extended Marcus theory, which has broad relevance to interpretation of charge transfer data, including multiple-site concerted electron proton transfer reaction data.
In conclusion, concerted multiple changes rather than single or few perturbations of death receptor signalling are likely to be responsible for the resistance of pancreatic adenocarcinoma cells to CD95- and TRAIL-R-mediated apoptosis.
Many of these are highly divergent in their protein-coding regions yet contain a conserved sequence motif in their 5' UTRs which appears to have been maintained by multiple events of concerted evolution.
Second, restriction of mutagenesis to small zones, even if randomly chosen, could promote high-level multiple mutations (concerted evolution) within genes without causing deleterious mutations throughout the genome (Ninio, 1996; Ponder et al., 2005; Yang et al., 2008).
Also, the average nucleotide heterozygosity at the hsp82 locus was 0.0016, compared to a much higher average nucleotide difference of 0.024 among mmr-b copies within an isolate, suggesting multiple copies homogenized by concerted evolution rather than allelic variation.
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